The Hydro4U project will adapt European technologies to Central Asia, demonstrating viability in a forward-looking cross-border water-food-energy-climate nexus. Price-competitiveness will be assured through design alterations based on a prior analysis of unexploited sustainable small-scale hydropower potential in Central Asia. Hydro4U will install and assess two demo plants: an eco-friendly low-head run-of-river plant and a medium-head plant, both with radically reduced planning and construction costs that do not compromise efficiency. These solutions will be fit-for-purpose based on innovation, modularization, meaning a radically simplified structural concept, with longevity, eco-compatibility and socio-political acceptance. The CHELSA data is used for current and future modelling of hydrological processes in the project in collaboration with the hydrosolutions GmbH in Zurich, Switzerland.